Umbreen Rashid
GC Women University, PakistanQuaid-i-Azam University, Pakistan
Title: In vivo assessment of anti-inflammatory activity of extract and fractions from Fagonia olivieri
Biography
Biography: Umbreen Rashid
Abstract
Objective & Purpose: The crude methanolic extract of Fagonia olivieri and its derived fractions were evaluated for their antiinflammatory potential in Sprague-Dawley rats. Materials & Methods: Carrageenan induced hind paw edema model was employed to determine anti-inflammatory activity of extracts. Results: The ethyl acetate fraction showed highest inhibition (25.516%) among all the extracts compared to the control rats. The standard drug Diclofenac Potassium (10 mg/kg bw) showed 35.106% inhibition. The aqueous and n-butanol fractions produced 21.512 and 10.983% inhibition respectively. The least value of inhibition was shown by methanol extract (3.853%). Conclusion & Discussion: The significant anti-inflammatory effect revealed by the ethyl acetate and aqueous fractions of Fagonia olivieri may be due to inhibition of prostaglandin-like substances. Anti-inflammatory potential could be assigned to chemical compounds like flavonoids, tannins, saponins, triterpenes and sterols. Tannins and flavonoids are known to inhibit prostaglandin synthesis.